Antibacterial Distribution and Drug–Drug Interactions in Cancer Patients

I am always surprised again how variable and unpredictable pharmacokinetic parameters of antibacterial drugs in severely ill cancer patients are.  With approved antibacterial drug dosages the probability of attaining the required drug exposure and PK/PD target is quite low. In other words, the risk for the individual patient to be insufficiently treated is very high. Though strategies for optimized dosage regimens exist the only way of improving results is applying individualized dosing regimens based on therapeutic drug monitoring.

In collaboration with my colleague Markus Zeitlinger (University of Vienna) I reviewed the topic “Antibacterial Distribution and Drug–Drug Interactions in Cancer Patients”. The book chapter of  the renowned text book series Principles and Practice of Cancer Infectious Diseases has just been published.

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s