Antibacterial Distribution and Drug–Drug Interactions in Cancer Patients
June 18, 2011 Leave a comment
I am always surprised again how variable and unpredictable pharmacokinetic parameters of antibacterial drugs in severely ill cancer patients are. With approved antibacterial drug dosages the probability of attaining the required drug exposure and PK/PD target is quite low. In other words, the risk for the individual patient to be insufficiently treated is very high. Though strategies for optimized dosage regimens exist the only way of improving results is applying individualized dosing regimens based on therapeutic drug monitoring.
In collaboration with my colleague Markus Zeitlinger (University of Vienna) I reviewed the topic “Antibacterial Distribution and Drug–Drug Interactions in Cancer Patients”. The book chapter of the renowned text book series Principles and Practice of Cancer Infectious Diseases has just been published.