May 26, 2014 Leave a comment
Since the introduction of antibacterial drugs, dosing concepts have evolved considerably. Distinct refinements of dosing strategy have been incorporated into practice over time to deal more effectively with different patient groups and to retain the utility of particular drugs. In recent years, individualized dosing in critically ill patients based on software programs that calculate individual PK factors and required doses proved to be an essential part of the antibacterial treatment strategy.
We recently published a review on individualised dosing for critically ill patients in Lancet Infectious Diseases. In this review, we explore the challenges related to patients and pathogens that contribute to inadequate antibiotic dosing and discuss how to implement a process for individualised antibiotic therapy that increases the accuracy of dosing and optimises care for critically ill patients.
Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
Jason A Roberts, Mohd H Abdul-Aziz, Jeff rey Lipman, Johan W Mouton, Alexander A Vinks, Timothy W Felton, William W Hope, Andras Farkas, Michael N Neely, Jerome J Schentag, George Drusano, Otto R Frey, Ursula Theuretzbacher, Joseph L Kuti, on behalf of The International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases