Non-traditional antibacterial therapeutic options and challenges

This review summarizes the progress and setbacks of non-traditional approaches. The development of non-traditional treatments suffers similar challenges faced by developers of conventional antibiotics; however, most of these new strategies have additional and considerable hurdles before it can be shown that they are safe and provide a meaningful clinical benefit to patients. While there is a considerable interest in the opportunities that non-traditional approaches will bring to treating bacterial infections, it is likely that effective treatments will be limited to healthcare settings with the best diagnostic and financial resources and healthcare systems that are able to financially support a strong growth of high-cost individual (personalized) medicines and thus to high-income countries.

Non-traditional Antibacterial Therapeutic Options and Challenges. Theuretzbacher U, Piddock LJV. Cell Host Microbe. 2019, 26(1):61-72.