May 14, 2011 Leave a comment
Zeitlinger MA, Derendorf H, Mouton JW, Cars O, Craig WA, Andes D, Theuretzbacher U.
Antimicrob Agents Chemother. 2011 May 2.
This publication aimed at “getting the in vitro testing right”. It was intended to raise awareness concerning fundamental flaws of in vitro testing to assess the impact of protein binding and the conclusions that are drawn from the results. We published a similar article two years ago that aimed at issues in testing and interpreting tissue concentrations: Tissue concentrations: do we ever learn? (JAC 2008)
Mouton JW, Theuretzbacher U, Craig WA, Tulkens PM, Derendorf H, Cars O.
J Antimicrob Chemother. 2008 Feb;61(2):235-7. Review